Smoking light cigarettes acutely reduced coronary flow reserve to a similar extent as regular cigarettes (mean CFR 2.31 vs 2.21; P=0.678).
RCT (n=20)
Single-blind, open-label
Does smoking light cigarettes have different acute effects on coronary flow reserve compared to regular cigarettes in healthy volunteers?
Smoking light cigarettes causes similar acute impairment of coronary microvascular function as regular cigarettes, indicating they do not offer a cardiovascular safety benefit.
Absolute Event Rate: 2.31% vs 2.21%
p-value: p=0.678
BACKGROUND: To date, there has been no study comparing the possible acute effects on coronary microvascular functions of smoking light cigarettes (those with low tar and nicotine yield) and regular cigarettes. METHODS: Twenty healthy volunteers (8 women and 12 men; mean age, 25.8 +/- 5.8 years) were included in a single-blind, open-label, cross-over study to compare the effects of smoking light cigarettes (containing 0.6 mg nicotine, 8 mg tar, 9 mg carbon monoxide) and smoking regular cigarettes (containing 0.9 mg nicotine, 12 mg tar, 12 mg carbon monoxide) on coronary flow reserve (CFR). For each participant, CFR values were measured at baseline, after smoking 2 regular or light cigarettes, and 15 days later after smoking 2 cigarettes of the other kind. RESULTS: After smoking 2 cigarettes, CFR values declined from 2.8 +/- 0.56 (baseline) to 2.31 +/- 0.51 after smoking light cigarettes (P = .003), and from 2.8 +/- 0.56 (baseline) to 2.21 +/- 0.45 after smoking regular cigarettes (P < .001). After smoking light and regular cigarettes, CFR values were similar (P = .678). CONCLUSIONS: Light cigarette smoking has similar acute detrimental effects on coronary microvascular function and CFR as does regular cigarette smoking.
Çiftçi et al. (Wed,) conducted a rct in Healthy volunteers (n=20). Light cigarettes vs. Regular cigarettes was evaluated on Coronary flow reserve (CFR) (p=0.678). Smoking light cigarettes acutely reduced coronary flow reserve to a similar extent as regular cigarettes (mean CFR 2.31 vs 2.21; P=0.678).