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A nondenaturing zwitterionic detergent for membrane biochemistry: design and synthesis. | Synapse

November 1, 1980Proceedings of the National Academy of Sciences364 citationsOpen Access

A nondenaturing zwitterionic detergent for membrane biochemistry: design and synthesis.

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LHLeonard M. HjelmelandUniversity of California, Davis

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Abstract

The synthesis and evaluation of a new detergent that is a zwitterionic derivative of cholic acid is presented. This detergent combines the useful properties of both the sulfobetaine-type detergents and the bile salt anions. The new detergent proved to be effective at solubilizing membrane proteins in a nondenatured state.

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Leonard M. Hjelmeland (1980) studied this question.

synapsesocial.com/papers/6a8932eb055af99351621170 https://doi.org/10.1073/pnas.77.11.6368

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