Elevated serum C-reactive protein was independently associated with a significantly larger intima to media thickness of the common carotid artery (1.05 mm vs. 0.92 mm; p < 0.05).
Observational (n=411)
Is elevated C-reactive protein associated with increased intima to media thickness of the common carotid artery in neurological inpatients?
Elevated serum CRP is independently associated with increased carotid intima-media thickness, supporting the link between systemic inflammation and subclinical atherosclerosis.
Absolute Event Rate: 1.05% vs 0.92%
p-value: p=< 0.05
In this study, we analyzed the relationship between serum C-reactive protein (CRP) and the intima to media thickness (IMT) of the common carotid artery in 411 consecutive neurological inpatients (215 males, mean age 64.1 years). The CRP concentration was determined within 12 h and patients were subdivided according to the CRP level. Patients with an elevated CRP (n = 149) showed a significantly larger IMT 1.05 mm (95% confidence interval (CI) 1.02-1.09) vs. 0.92 mm (95% CI 0.89-0.94). Multivariate linear regression analysis revealed that an elevated CRP level, age, pack-years of smoking, body mass index, incidence of diabetes mellitus and ischemic stroke were independently associated with an increased IMT (p < 0.05).
Winbeck et al. (Tue,) conducted a observational in Neurological inpatients (n=411). Elevated C-reactive protein vs. Non-elevated C-reactive protein was evaluated on Intima to media thickness (IMT) of the common carotid artery (p=< 0.05). Elevated serum C-reactive protein was independently associated with a significantly larger intima to media thickness of the common carotid artery (1.05 mm vs. 0.92 mm; p < 0.05).