Does AT1 receptor blockade modulate pathological proliferation and inflammation in the contralateral kidney and heart following prolonged unilateral renal ischemia?
Prolonged unilateral renal ischemia induces systemic inflammatory and proliferative changes in the heart and contralateral kidney that can be attenuated by AT1 receptor blockade.
Rather than affecting a single organ, the present study demonstrates that after prolonged renal ischemia, the contralateral kidney and heart undergo changes in growth factor and chemokine expression, resulting in pathological proliferation and inflammation that can be modulated by blockade of the AT1 receptor.
Tokuyama et al. (Fri,) studied this question.
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