Two Caucasian male patients with Japanese-type apical hypertrophic cardiomyopathy experienced malignant arrhythmias at ages 42 and 52, suggesting an increased risk of sudden cardiac death.
Case Report (n=2)
Apical hypertrophic cardiomyopathy may carry an increased risk of sudden cardiac death due to malignant arrhythmias, challenging the belief that it has a benign prognosis.
Apical hypertrophic cardiomyopathy (HCM) is a specific variant of HCM. This disease has been first described in Japan where the prevalence is much higher than in the western world. The prognosis of apical HCM with regard to sudden cardiac death is believed to be better than that of common HCM. We present, however, two male caucasian patients with apical HCM and malignant arrhythmias. Both patients had marked apical hypertrophy on echocardiography, 'giant' negative T-waves on the ECG and spade-like configuration of the left ventricle on angiography. The first patient had been successfully recussitated from cardiac arrest at the age of 52 years. The second patient had a syncope at the age of 42 years and had non-sustained ventricular tachycardia. In both cases, a cardioverter-defibrillator was implanted and treatment with verapamil was initiated. These observations suggest that the risk of sudden cardiac death might be increased not only in common HCM, but also in Japanese-type apical HCM.
Ridjab et al. (Tue,) conducted a case report in Apical hypertrophic cardiomyopathy (n=2). Cardioverter-defibrillator and verapamil was evaluated. Two Caucasian male patients with Japanese-type apical hypertrophic cardiomyopathy experienced malignant arrhythmias at ages 42 and 52, suggesting an increased risk of sudden cardiac death.