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The success of fluorination in improving molecular properties over a wide range of applications (including pharmaceuticals,1 agrochemicals,2 materials,3 and crystal engineering4) has been remarkable. Up to 20 % of the pharmaceuticals prescribed or administered in the clinic, and a third of the leading 30 blockbuster drugs, contain at least one fluorine atom1a and 30–40 % of currently marketed agrochemicals contain fluorine.5
Graton et al. (Thu,) studied this question.
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