Captopril (0.5 mg/kg/h) prevented remodeling of 30-100 microm pulmonary arteries in hypoxia-induced pulmonary hypertension but had no effect on monocrotaline-induced pulmonary hypertension.
Do structural characteristics of pulmonary arteries differ between hypoxia- and monocrotaline-induced pulmonary hypertension rat models, and what is the effect of captopril?
Angiotensin II plays a pivotal role in pulmonary artery remodeling in hypoxia-induced, but not monocrotaline-induced, pulmonary hypertension in rats.
In the present study we analyzed structural characteristics of muscular pulmonary arteries and arterioles in two classic models of pulmonary hypertension, the rat hypoxia and monocrotaline models. We hypothesized that an increase in medial cross-sectional area would result in reduction of the lumen area and that these parameters would correlate with the increase in pulmonary artery pressure (PAP). Four weeks after a single injection of monocrotaline (MCT) or after 4 wk of hypoxic exposure the rats were killed. Both MCT and chronic hypoxia induced right ventricular hypertrophy. In separate groups of rats both MCT and chronic hypoxia increased PAP. MCT increased the media cross-sectional area of pulmonary arteries with an external diameter between 30-100 microm and 101-200 microm and reduced the lumen area of pulmonary arteries with an external diameter between 101-200 microm. Chronic hypoxia only slightly increased the media cross-sectional area without a change of the lumen area. Both MCT and hypoxia increased the percentage of partly muscularized and muscularized arterioles. The angiotensin-converting enzyme (ACE) inhibitor captopril (0.5 mg/kg/h) had no effect on MCT-induced pulmonary hypertension, right ventricular hypertrophy, and pulmonary artery remodeling. In chronic hypoxic rats it prevented an increase in medial cross-sectional area of pulmonary arteries with an external diameter between 30-100 microm and attenuated the increase in the percentage of muscularized arterioles, without any effect on the PAP. We conclude that MCT, in contrast to chronic hypoxia, induces structural changes of muscular pulmonary arteries with an external diameter between 101-200 microm which may contribute to an increased PAP and right ventricular hypertrophy. These data also suggest that angiotensin II plays a pivotal role in remodeling of pulmonary arteries in hypoxia but not in MCT-induced pulmonary hypertension.
Suylen et al. (Fri,) conducted a other in Pulmonary hypertension. Monocrotaline, chronic hypoxia, and captopril vs. Control/each other was evaluated on Structural characteristics of muscular pulmonary arteries and arterioles, right ventricular hypertrophy, and pulmonary artery pressure. Captopril (0.5 mg/kg/h) prevented remodeling of 30-100 microm pulmonary arteries in hypoxia-induced pulmonary hypertension but had no effect on monocrotaline-induced pulmonary hypertension.