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Successful applications of nanoparticles are often limited by insufficient nanoparticle stability due to low binding affinity of dispersants. However, excellent Fe 3 O 4 nanoparticle stability was reported in a recent study ( Nano Lett. 2009, 9, 4042−4048) that compared different catechol derivative-anchored low molecular weight dispersants. Here, we investigate mechanistic binding aspects of five different anchors from this study that showed radically different efficiencies as dispersant anchors, namely nitroDOPA, nitrodopamine, DOPA, dopamine, and mimosine, using electron paramagnetic resonance, Fourier transform infrared spectroscopy, and UV−vis spectroscopy. We demonstrate enhanced electron delocalization for nitrocatechols binding to Fe 2+ compared to unsubstituted catechols if they are adsorbed on Fe 3 O 4 surfaces. However a too high affinity of mimosine to Fe 3+ was shown to lead to gradual dissolution of Fe 3 O 4 nanoparticles through complexation followed by dissociation of the complex. Thus, the binding affinity of anchors should be optimized rather than maximized to achieve nanoparticle stability.
Amstad et al. (2010) studied this question.