Black-Americans with VTE had significantly higher rates of pulmonary embolism, higher BMI, and more comorbidities, but fewer transient risk factors compared to White-Americans.
Cross-Sectional (n=2,397)
Yes
Do demographic and baseline characteristics, including VTE risk factors, differ between White- and Black-Americans with venous thromboembolism?
White and Black Americans with VTE differ significantly in baseline characteristics, with Blacks having higher rates of idiopathic VTE and comorbidities but lower rates of transient risk factors and inherited thrombophilias.
When compared with Whites, Black-Americans may have a 40% higher incidence venous thromboembolism (VTE) incidence. However, whether other VTE characteristics and risk factors vary by race is uncertain. To compare demographic and baseline characteristics among White- and Black-Americans with VTE, we used data prospectively collected from consecutive consenting adults enrolled in seven Centers for Disease Control (CDC) Thrombosis and Hemostasis Centers from August 2003 to March 2009. These characteristics were compared among Whites (n = 2002) and Blacks (n = 395) with objectively diagnosed VTE, both overall, and by age and gender. When compared with Whites, Blacks had a significantly higher proportion with pulmonary embolism (PE), including idiopathic PE among Black women, and a significantly higher proportion of Blacks were women. Blacks had a significantly higher mean BMI and a significantly lower proportion with recent surgery, trauma or infection, family history of VTE, and documented thrombophilia (solely from reduced factor V Leiden and prothrombin G20210A prevalence). Conversely, Blacks had a significantly higher proportion with hypertension, diabetes mellitus, chronic renal disease and dialysis, HIV, and sickle cell disease. When compared with White women, Black women had a significantly lower proportion with recent oral contraceptive use or hormone therapy. We conclude that Whites and Blacks differ significantly regarding demographic and baseline characteristics that may be risk factors for VTE. The prevalence of transient VTE risk factors and idiopathic VTE among Blacks appears to be lower and higher, respectively, suggesting that heritability may be important in the etiology of VTE among Black-Americans.
Heit et al. (Tue,) conducted a cross-sectional in Venous thromboembolism (n=2,397). Black race vs. White race was evaluated on Demographic and baseline characteristics including pulmonary embolism, BMI, and comorbidities. Black-Americans with VTE had significantly higher rates of pulmonary embolism, higher BMI, and more comorbidities, but fewer transient risk factors compared to White-Americans.