Long-term timolol treatment after myocardial infarction led to a small but significant increase in heart size from baseline, contrasting with a decrease in the placebo group.
RCT (n=241)
Double-blind
Myocardial Infarction (n=241)
Timolol vs Placebo
Changes in heart size
The effect of long-term timolol treatment on heart size after myocardial infarction was evaluated by X-ray in a double-blind study including 241 patients (placebo 126, timolol 115). The follow-up period was 12 months. The timolol-treated patients showed a small but significant increase in heart size from baseline in contrast to a decrease in the placebo group. These differences may be caused by timolol-induced bradycardia and a compensatory increase in end-diastolic volume. The timolol-related increase in heart size was observed only in patients with normal and borderline heart size. In patients with cardiomegaly, the increase in heart size was similar in both groups. After re-infarction, heart size increased in the placebo group and remained unchanged in the timolol group.
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T Gundersen
Sørlandet Hospital Arendal
Kjell Trætteberg
Stavanger University Hospital
Per K. Rønnevik
Thorax Foundation
Acta Medica Scandinavica
Stavanger University Hospital
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Gundersen et al. (Thu,) conducted a rct in Myocardial Infarction (n=241). Timolol vs. Placebo was evaluated on Changes in heart size. Long-term timolol treatment after myocardial infarction led to a small but significant increase in heart size from baseline, contrasting with a decrease in the placebo group.
synapsesocial.com/papers/6a0efeb7a14f152feafa2055 — DOI: https://doi.org/10.1111/j.0954-6820.1984.tb04966.x
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