June 11, 1982

HEL Cells: A New Human Erythroleukemia Cell Line with Spontaneous and Induced Globin Expression

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Abstract

A new human erythroleukemia cell line has been established. This line, designated HEL, is capable of spontaneous and induced globin synthesis, producing mainly Gγ and Aγ chains. Embryonic chains (ε, ζ) and α chains are detectable in very small amounts; β chains are undetectable. This line provides a new model system for studying aspects of erythroid cell differentiation and differential globin gene expression.

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Martin et al. (Fri,) studied this question.

synapsesocial.com/papers/695c15383e1e1182ade53794 https://doi.org/https://doi.org/10.1126/science.6177045

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5Isoelectric focusing of human hemoglobin: its application to screening, to the characterization of 70 variants, and to the study of modified fractions of normal hemoglobins1978 · 350 citations

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