December 14, 1988
View Full PaperThe Structure of the Polycyclic Nonadecapeptide Ro 09‐0198
Key Points
Key points are not available for this paper at this time.
Abstract
Abstract The conventional determination of the amino‐acid sequence of the peptide antibiotic Ro 09‐0198 was prevented by four cyclizations via side chains. The joint application of NMR spectroscopy at highest field and automated Edman degradation yielded a complete determination of the connectivity pattern. The three‐dimensional structure derived from NOE data exhibits an interesting separation of amino acids with hydrophilic and hydrophobic side chains.