Electrocardiographic Alterations Produced by a Decrease in Plasma pH, Bicarbonate and Sodium as Compared with those Produced by an Increase in Potassium

The effects of a decrease in plasma pH, bicarbonate and sodium on the electrocardiographic pattern are compared with those produced by elevation of serum potassium and lithium in the dog. The electrocardiographic alterations were found to be similar in form and progression. The alterations can be correlated with those found in isolated nerve and muscle preparations.