Higher pulmonary artery end-diastolic pressure (>20 mmHg) in acute myocardial infarction was associated with larger infarct size (99g), reduced cardiac function (P<0.001), and 60% mortality.
Observational (n=82)
In acute myocardial infarction, elevated pulmonary artery end-diastolic pressure correlates with larger infarct size, impaired cardiac function, and increased mortality.
p-value: p=< 0.001
In 82 patients with acute myocardial infarction, observed haemodynamic changes were compared with the average maximal serum enzyme rise and the infarct size, as calculated from serial determinations of creatine phosphokinase concentration. For this purpose, patients were divided into 3 groups according to their pul- monary artery end-diastolic pressure at the time of admission. There were I9 patients in group I with pulmonary artery end-diastolic pressure 20 mmHg, who had an average infarct size of 99g. Cardiac index (19 0-2 1./min/m2), and stroke work index (27.5 5-7g iM/iM2) declined significantly (P< o.ooi). Mean end-diastolic pressure rose to 28-3 xI@ mmHg. Mortality in group III (6o%) was mainly due to cardio- genic shock.
Mathey et al. (Fri,) conducted a observational in acute myocardial infarction (n=82). Pulmonary artery end-diastolic pressure at admission vs. Different levels of pulmonary artery end-diastolic pressure (<12 mmHg, 12-20 mmHg, >20 mmHg) was evaluated on Relation between haemodynamic changes, infarct size, and cardiac function (p=< 0.001). Higher pulmonary artery end-diastolic pressure (>20 mmHg) in acute myocardial infarction was associated with larger infarct size (99g), reduced cardiac function (P<0.001), and 60% mortality.