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Injection of plasma from thrombocytopenic donor rats resulted in an increase in the endomitotic index of megakaryocytes of recipient mice 32 hr after the initial treatment with plasma. The results suggested a dose-response relationship between the amount of plasma administered and the degree of stimulation of megakaryocytopoiesis. These findings demonstrate that an agent capable of stimulating megakaryocytopoiesis is released in response to thrombocytopenia and that this factor can be successfully transferred between species. They also substantiate the assumption that the increase in peripheral platelet numbers and in platelet labeling after administration of presumptive TSF occurs via stimulation of megakaryocytopoiesis.
Odell et al. (Thu,) studied this question.