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REISMAN, Zuelzer and Mitani1 described polyploidy and endoreduplication of chromosomes in a patient being treated for acute leukemia. They ascribed these abnormalities to a primary chromosomal disorder in the leukemic cells. In this case, no baseline chromosome studies were obtained, and the specific chemotherapeutic agent that the patient was receiving at the time of study was not mentioned.In a patient with acute leukemia reported by Bottura and Ferrari2 polyploidy and endoreduplication were noted in a single bone-marrow examination obtained while the patient was receiving 6-mercaptopurine. A chromosomal analysis showed the normal diploid number before treatment was started. They suggested . . .
Nasjleti et al. (Thu,) studied this question.