This European consensus document identifies reasons for the lack of progress in acute heart failure trials and provides pragmatic solutions to simplify future therapeutic endeavors.
This consensus document outlines pragmatic solutions to overcome the challenges in designing clinical trials and developing new therapies for acute heart failure.
This European consensus document aims to identify the main reasons for the apparent lack of progress in the introduction of new medicines for acute heart failure. Relevant issues include not only the heterogeneity of the patient group but also the pharmacology of the medicines themselves and the design of the trials. Above all, this document attempts to provide some pragmatic solutions to this complex syndrome to simplify the execution of meaningful therapeutic endeavours in this area of undoubted unmet clinical need in the future.
McDonagh et al. (2011) conducted a review in Acute heart failure. This European consensus document identifies reasons for the lack of progress in acute heart failure trials and provides pragmatic solutions to simplify future therapeutic endeavors.