Does standard dose enoxaparin provide reliable anti-Xa activity for VTE prevention in critically ill multiple trauma patients?
Standard VTE prophylaxis dosing of enoxaparin yields unpredictable anticoagulation levels in critically ill trauma patients, especially those with peripheral edema, suggesting a potential need for monitoring or dose adjustment.
The standard dose of enoxaparin recommended for the prevention of VTE following multiple trauma provides unreliable and highly variable anti-Xa activity in critically ill trauma patients, and is strongly affected by the presence of significant peripheral edema.
Haas et al. (Thu,) studied this question.