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Bidirectional SV40 Transcription Mediated by Tandem Sp1 Binding Interactions | Synapse

November 1, 1985

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Bidirectional SV40 Transcription Mediated by Tandem Sp1 Binding Interactions

DGDavid GidoniAgricultural Research Organization JKJames T. KadonagaUniversity of California, San Diego HBHugo A. Barrera‐SaldañaUniversidad Regiomontana

Key Points

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Abstract

The 21-base pair repeat elements of the SV40 promoter contain six tandem copies of the GGGCGG hexanucleotide (GC-box), each of which can bind, with varying affinity, to the cellular transcription factor, Sp1. In vitro SV40 early RNA synthesis is mediated by interaction of Sp1 with GC-boxes I, II, and III, whereas transcription in the late direction is mediated by binding to GC-boxes III, V, and VI.

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Cite This Study

Gidoni et al. (Fri,) studied this question.

synapsesocial.com/papers/6a1c4635b33628da419d5ec3 https://doi.org/https://doi.org/10.1126/science.2996137

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