November 14, 2008
Effect of Sotalol on Arrhythmias and Exercise Tolerance in Patients with Hypertrophic Cardiomyopathy
Key Result
Sotalol significantly improved exercise time compared to placebo (10.6 vs 9.4 min; p<0.01) and suppressed supraventricular and ventricular arrhythmias in patients with hypertrophic cardiomyopathy.
Study Design
Type
RCT (n=30)
Blinding
Double-blind
PICO
Population
Hypertrophic cardiomyopathy (n=30)
Intervention / Comparator
Sotalol vs Placebo (320 mg/day (short-term); 160-480 mg/day (long-term))
Primary Outcome
Exercise time, p=< 0.01
Main Result
Absolute Event Rate: 10.6% vs 9.4%
p-value: p=< 0.01
Abstract
The effect of sotalol on exercise tolerance and incidence of arrhythmias was studied in 30 patients with hypertrophic cardiomyopathy (HCM). In this short-term, double-blind, cross-over study, exercise time on sotalol (320 mg/day) was significantly longer than on placebo (10.6 +/- 4.0 vs. 9.4 +/- 3.6 min; p 0.2) after 6 months of treatment. It is concluded that sotalol significantly improves exercise tolerance and is effective in suppressing both supraventricular and ventricular arrhythmias in patients with HCM.
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Authors
Michał Tendera
General Cardiology
A
Anna Wycisk
Medical University of Silesia
A
Adam Schneeweiss
Roche (Switzerland)
Journals
C
Cardiology
Actions
Institutions
Cardiovascular Research Foundation
Silesian Center for Heart Disease
References and Citations
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