Carvedilol administration protected against myocardial fibrosis and decreased the mortality rate in TO2 hamsters compared to untreated controls.
Does carvedilol prevent myocardial fibrosis and reduce mortality in a hamster model of dilated cardiomyopathy?
Carvedilol improves survival and attenuates myocardial fibrosis in a hamster model of progressive dilated cardiomyopathy.
The objective of the present study was to determine if carvedilol protects against myocardial degeneration and fibrotic change, and reduces mortality in TO2 hamsters. Carvedilol was administered intraperitoneally to 8 week-old TO2 hamsters for 21 weeks at a dose of 11 mg/kg/day. There were 15 TO2 hamsters in the carvedilol group (group C) and 10 in the untreated group (group N). The control group consisted of 11 Fb hamsters (group F). The mortality rate was determined from the number of surviving hamsters after 29 weeks. Myocardial fibrosis was evaluated by MRI and histopathological examination. EF and LVDd were determined by echocardiography at 8 and 29 weeks, while the MRI score was calculated at 29 weeks. Mortality, histopathological fibrosis, and MRI score were all lower in group C than in group N. Carvedilol had a protective effect against myocardial fibrosis and decreased the mortality rate in TO2 hamsters.
Nanjo et al. (Sun,) conducted a other in Myocardial fibrosis and mortality (n=36). Carvedilol vs. Untreated TO2 hamsters and Fb hamsters was evaluated on Mortality and myocardial fibrosis. Carvedilol administration protected against myocardial fibrosis and decreased the mortality rate in TO2 hamsters compared to untreated controls.