Six cases of vaccine-associated paralytic poliomyelitis caused by vaccine-derived polioviruses were identified in immunodeficient children in Iran between 1995 and 2008.
Observational (n=6)
Changing to an inactivated polio vaccine schedule and screening neonates for immunodeficiencies could reduce the risk of vaccine-associated paralytic poliomyelitis.
To determine the prevalence of vaccine-associated paralytic poliomyelitis (VAPP) in immunodeficient infants, we reviewed all documented cases caused by immunodeficiency-associated vaccine-derived polioviruses in Iran from 1995 through 2008. Changing to an inactivated polio vaccine vaccination schedule and introduction of screening of neonates for immunodeficiencies could reduce the risk for VAPP infection.
Shahmahmoodi et al. (2010) conducted an observational in Vaccine-associated paralytic poliomyelitis (VAPP) in immunodeficient children (n=6). Oral polio vaccine (OPV) was evaluated on Characteristics and outcomes of immunodeficiency-associated vaccine-derived polioviruses (iVDPVs). Six cases of vaccine-associated paralytic poliomyelitis caused by vaccine-derived polioviruses were identified in immunodeficient children in Iran between 1995 and 2008.