Complete surgical excision of retroperitoneal sarcoma had an 85% probability of local recurrence by 5 years (95% CI 56-99), highlighting the limitations of surgery and poor overall prognosis.
Cohort (n=120)
No
What are the long-term survival and recurrence outcomes following surgery for retroperitoneal sarcoma?
The prognosis for retroperitoneal sarcoma remains poor, with a high rate of local recurrence even after apparently complete surgical excision.
A retrospective analysis was undertaken of 120 patients with retroperitoneal sarcoma referred to the Royal Marsden Hospital over a period of 20 years. The actuarial 5-year survival rate of all cases following referral was 29 per cent. On univariate and multivariate analysis the principal factors associated with an unfavourable prognosis were the presence of metastases, poor performance status at presentation, high tumour grade and incomplete excision of the primary tumour. The single most important factor affecting the ability to remove the primary tumour completely was multiple organ involvement. After apparently complete excision, however, the probability of local recurrence by 5 years was 85 per cent (95 per cent confidence interval 56-99). The prognosis of patients with retroperitoneal sarcoma is poor.
Alvarenga et al. (Thu,) conducted a cohort in Retroperitoneal sarcoma (n=120). Surgery (complete excision of primary tumour) was evaluated on Probability of local recurrence by 5 years after complete excision (95% CI 56-99). Complete surgical excision of retroperitoneal sarcoma had an 85% probability of local recurrence by 5 years (95% CI 56-99), highlighting the limitations of surgery and poor overall prognosis.