Key points are not available for this paper at this time.
A library of diarylurea IGFR inhibitors was screened for activity against chloroquine-sensitive (3D7) and chloroquine-resistant (K1) strains of Plasmodium falciparum. The 4-aminoquinaldine-derived diarylureas displayed promising antimalarial potency. Further exploration of the B ring of 4-aminoquinaldinyl ureas allowed identification of several quinaldin-4-yl ureas 413, 39 and 413, 58 sufficiently potent against both 3D7 and K1 strains to qualify as bone fide leads.
Zhang et al. (Thu,) studied this question.