Does preinjury statin use affect the risk of multiple organ failure after injury?
Preinjury statin use is associated with a higher risk of multiple organ failure after severe injury, contrary to previous analyses.
PIS use was independently associated with a higher risk of MOF postinjury. These results are contrary to previous analyses. The protective effect of statins may be lost in the severely injured, and modulation of the inflammatory response may result in higher morbidity. Further studies are required to better understand the impact and potential therapeutic utility of this commonly prescribed medication both before and after injury.
Neal et al. (Tue,) studied this question.
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