What is the incidence of peripheral edema and associated withdrawal rate with calcium channel blocker therapy?
Peripheral edema is a clinically significant adverse effect of calcium channel blockers that leads to treatment discontinuation in over 5% of patients, though risk can be mitigated by using non-dihydropyridines or lipophilic dihydropyridines.
The incidence of peripheral edema progressively increased with duration of CCB therapy up to 6 months. Over the long term, more than 5% of patients discontinued CCBs because of this adverse effect. Edema rates were lower with both non-DHPs and lipophilic DHPs.
Makani et al. (Tue,) studied this question.
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