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ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDo Enzymes Stabilize Transition States by Electrostatic Interactions or pKa Balance: The Case of Triose Phosphate Isomerase (TIM)?Giuliano Alagona, Caterina Ghio, and Peter A. KollmanCite this: J. Am. Chem. Soc. 1995, 117, 39, 9855–9862Publication Date (Print):October 1, 1995Publication History Published online1 May 2002Published inissue 1 October 1995https://pubs.acs.org/doi/10.1021/ja00144a011https://doi.org/10.1021/ja00144a011research-articleACS PublicationsRequest reuse permissionsArticle Views233Altmetric-Citations64LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Alagona et al. (Sun,) studied this question.