In women with a history of placental syndrome, concomitant metabolic syndrome increased the risk of cardiac diastolic dysfunction (24% vs 6.3%; adjusted OR 6.09, 95% CI 2.64-14.04).
Cohort
Does the presence of metabolic syndrome increase the risk of cardiac diastolic dysfunction in women with a history of placental syndrome?
In women with a history of placental syndrome, concomitant metabolic syndrome is associated with a significantly increased risk of cardiac diastolic dysfunction.
Effect estimate: adjusted OR 6.09 (95% CI 2.64-14.04)
Absolute Event Rate: 24% vs 6.3%
OBJECTIVE: To estimate whether women with a recent history of a placental syndrome and concomitant metabolic syndrome have reduced cardiac diastolic function. METHODS: In this cohort study, women with a history of a placental syndrome were included. We assessed body mass index, blood pressure, fasting serum lipids, glucose and insulin levels, and 24-hour urinary protein and albumin output after an interval of at least 6 months postpartum. Cardiac diastolic function was assessed by echocardiography. RESULTS: Metabolic syndrome was found in 22% of the women evaluated. Diastolic dysfunction was seen in 24% of the women with the metabolic syndrome compared with 6.3% in those without (odds ratio 4.77, 95% confidence interval 2.18-10.41; adjusted odds ratio 6.09, 95% confidence interval 2.64-14.04). Univariable analysis showed that all the constituents of the metabolic syndrome related to diastolic dysfunction. CONCLUSION: In women with a history of placental syndrome complicating pregnancy, the presence of metabolic syndrome increases the risk of cardiac diastolic dysfunction fourfold. LEVEL OF EVIDENCE: II.
Zandstra et al. (Thu,) conducted a cohort in Placental syndrome. Metabolic syndrome vs. No metabolic syndrome was evaluated on Cardiac diastolic dysfunction (adjusted OR 6.09, 95% CI 2.64-14.04). In women with a history of placental syndrome, concomitant metabolic syndrome increased the risk of cardiac diastolic dysfunction (24% vs 6.3%; adjusted OR 6.09, 95% CI 2.64-14.04).