Prior poliomyelitis was associated with a 13.4% reduction in motor-unit number and an 18.4% diminution in M-wave amplitude over 2 years (P < 0.001), twice the rate of normal aging.
Cohort (n=76)
Does denervation progress over time in patients with prior poliomyelitis?
Patients with prior poliomyelitis experience progressive denervation in both clinically affected and unaffected muscles at a rate faster than normal aging.
p-value: p=< 0.001
Motor unit number estimation was employed to assess muscle innervation in 76 patients with prior poliomyelitis. Of the 68 patients who were 60 years. Analysis of individual patients indicated that some were deteriorating more rapidly than others. These studies confirm that denervation progresses in patients with prior poliomyelitis in both clinically affected and unaffected muscles, and indicate that this progression is more rapid than that occurring in normal ageing.
Alan J. McComas (Fri,) conducted a cohort in Prior poliomyelitis (n=76). Prior poliomyelitis vs. Healthy subjects aged > 60 years was evaluated on Reduction in motor-unit number (p=< 0.001). Prior poliomyelitis was associated with a 13.4% reduction in motor-unit number and an 18.4% diminution in M-wave amplitude over 2 years (P < 0.001), twice the rate of normal aging.