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Research Paper | Synapse

January 26, 2010Open Access

Therapeutic Activation of Signal Transducer and Activator of Transcription 3 by Interleukin-11 Ameliorates Cardiac Fibrosis After Myocardial Infarction

Structured PICO

Does Interleukin-11 ameliorate cardiac fibrosis after myocardial infarction?

P

Population

Post-myocardial infarction models

I

Intervention

Interleukin-11 (IL-11)

O

Outcome

Cardiac fibrosissurrogate

Activation of the IL-11/glycoprotein 130/STAT3 axis may serve as a novel therapeutic strategy to reduce cardiac fibrosis following myocardial infarction.

Abstract

IL-11 attenuated cardiac fibrosis after MI through STAT3. Activation of the IL-11/glycoprotein 130/STAT3 axis may be a novel therapeutic strategy against cardiovascular diseases.

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Cite This Study

Obana et al. (Tue,) studied this question.

synapsesocial.com/papers/69bc7d73642c8354f461c81d https://doi.org/https://doi.org/10.1161/circulationaha.109.893677

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