The essential role of transient receptor potential vanilloid 1 in simvastatin‐induced activation of endothelial nitric oxide synthase and angiogenesis

Simvastatin-induced Ca(2+) influx may through the activation of TRPV1-TRPA1 signalling, which leads to phosphorylation of CaMKII, increases in the formation of TRPV1-CaMKII-AMPK-eNOS complex, eNOS activation, NO production and, ultimately, angiogenesis in ECs.