A 1-SD decrement in heart rate increase from 40% to 100% of maximal work capacity increased mortality risk by 41% in men with known or suspected CHD (HR 1.41; 95% CI 1.12-1.79).
Cohort (n=294)
Does an attenuated heart rate increase during the latter half of a maximal exercise test predict mortality in middle-aged men with known or suspected CHD?
An attenuated heart rate increase during the latter half of a maximal exercise test is an independent predictor of death in men with known or suspected CHD.
Hazard Ratio: 1.41 (95% CI 1.12–1.79)
AIMS: The objective is to study whether a heart rate (HR) increase from 40 to 100% of maximal work capacity in the exercise test (HR40-100) independently predicts mortality in men with known or suspected coronary heart disease (CHD). METHODS AND RESULTS: The subjects were 294 men, 42-61 years of age, from eastern Finland with known or suspected CHD but without use of HR-lowering medication at baseline. HR was measured at rest and during a maximal, symptom-limited exercise test. During an average follow-up of 11.0 years, there were 61 all-cause deaths. In Cox-multivariable model, mortality increased by 41% (95% confidence interval, 12-79%) with a 1-SD (15 b.p.m.) decrement in HR40-100. HR increase from rest to 40% of maximal work capacity was not associated with an increased risk of death. Synergism was observed between HR40-100 and workload achieved at HR of 100 b.p.m. so that men having low values for both these HR variables had a particularly adverse prognosis compared with men with high values for these variables. CONCLUSION: An attenuated HR increase particularly during the latter half of a maximal exercise test is an independent predictor of death in men with known or suspected CHD.
Savonen et al. (Sat,) conducted a cohort in known or suspected coronary heart disease (n=294). 1-SD decrement in heart rate increase from 40 to 100% of maximal work capacity (HR40-100) was evaluated on All-cause mortality (HR 1.41, 95% CI 1.12-1.79). A 1-SD decrement in heart rate increase from 40% to 100% of maximal work capacity increased mortality risk by 41% in men with known or suspected CHD (HR 1.41; 95% CI 1.12-1.79).