Long-lasting endurance exercise and higher exercise intensity induced significantly higher levels of soluble heat shock protein 72 (sHSP72) compared to shorter or moderate exercise.
Does the duration and intensity of endurance running affect the release of sHSP72 into peripheral blood in endurance athletes?
Long-lasting, competitive endurance exercise induces a more pronounced sHSP72 response compared with shorter, more intensive exercise, suggesting a duration- and intensity-dependent role in exercise-induced immune responses.
Soluble heat shock protein 72 (sHSP72) is suggested to play a role as a signalling molecule in the immune response to exercise. We were interested in whether duration and intensity of endurance running affect the level of inducible sHSP72 in the plasma/serum of endurance athletes. In the first part of the study, the influence of a continuous treadmill run of 60 min (CR) with an intensity of 75 % VO2max, a long treadmill run of 120 min (LR) with an intensity of 60 % VO2max, an extensive interval training program (IT; 10 x 1000 m, ca. 35 min, VO2max 88 %), and a competitive marathon run (MA) within 260 +/- 39 min (VO2max ca. 65 %) on the release of sHSP72 into the peripheral blood was tested. Blood samples were drawn before and directly after exercise, as well as 0.5, 1, 3, 24 h after exercise to determine sHSP72 levels. Secondly, we compared the effects of two exercise bouts with identical duration (23.7 +/- 7 min) but different intensities (Exhaustive exercise (ET) at 80 % VO2max vs. moderate exercise (MT) at 60 % VO2max) on sHSP72 concentration. The sHSP72 levels in plasma/serum were analyzed using an enzyme immunoassay specific for inducible HSP72 (Stressgen,Victoria, Canada). Early, significant increases of sHSP72 were detected immediately after all types of exercise with highest levels after MA. ET induced significantly higher levels of sHSP72 compared with MT. Long-lasting, competitive endurance exercise induced a more pronounced response of sHSP compared with more intensive but shorter exercise. Exercise intensity was also an important influencing factor. A duration- and intensity-dependent role for sHSP72 in the exercise-induced changes of the immune response may be assumed.
Fehrenbach et al. (Thu,) conducted a other in Endurance athletes. Endurance running of varying intensity and duration vs. Different exercise intensities and durations was evaluated on Release of sHSP72 into peripheral blood. Long-lasting endurance exercise and higher exercise intensity induced significantly higher levels of soluble heat shock protein 72 (sHSP72) compared to shorter or moderate exercise.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: