Genetic analysis of EV71 isolates from the 2011 epidemic in southern Vietnam revealed that 94% were genotype C4a and 6% were genotype C5, with no antigenic variants detected.
Cross-Sectional (n=148)
No
The 2011 EV71 epidemic in southern Vietnam was primarily driven by genotype C4a, highlighting the need for longitudinal surveillance to inform vaccination policy.
Absolute Event Rate: 94% vs 6%
Enterovirus 71 (EV71) frequently causes fatal infections in young children in Asia. In 2011, EV71 epidemics occurred in southern Vietnam. We conducted genetic and antigenic analysis of the EV71 isolates and found that 94% of them were genotype C4a related to two lineages circulating in China and 6% were genotype C5 which have circulated in Vietnam since 2003. Antigenic variants were not detected. EV71 vaccines are being developed. Longitudinal enterovirus surveillance data are critical to formulate vaccination policy in Vietnam.
Thoa et al. (Mon,) conducted a cross-sectional in Hand-foot-mouth disease (HFMD) / Enterovirus 71 infection (n=148). Enterovirus 71 was evaluated on Genotype distribution of EV71 isolates. Genetic analysis of EV71 isolates from the 2011 epidemic in southern Vietnam revealed that 94% were genotype C4a and 6% were genotype C5, with no antigenic variants detected.