To elucidate the clinical significance of negative T wave on electrocardiogram in patients with essential hypertension, the relation between negative T wave and left ventricular mass (LVM) was studied in 89 patients with essential hypertension. Left ventricular hypertrophy was defined as an LVM index of equal to or greater than 125g/m2. Essential hypertensive patients were classified into the following three groups: Group I (n=46) with neither left ventricular hypertrophy nor a history of hypertensive heart failure, Group II (n=33) with left ventricular hypertrophy and without a history of hypertensive heart failure, and Group III (n=10) with both left ventricular hypertrophy and a history of hypertensive heart failure. Negative T waves in essential hypertensive patients were observed in 4.3% of Group I, 51.5% of Group II and 100% of Group III. LVM indices in Groups I, II and III were 97±18(g/m2), 151±20 (p<0.01vs. I) and 238±23 (p<0.01vs. II), respectively. There was a significant relationship between the depth of negative T wave and LVM index (r=0.61, p<0.001). However, there was no significant difference in LVM index between Group II with negative T wave and without negative T wave. Essential hypertensive patients with more than 190g/m2 of LVM index developed hypertensive heart failure. These findings indicate that the negative T wave and its depth in patients with essential hypertension correlate well with LVM, but myocardial injury and ischemia associated with ventricular hypertrophy also have some influences on the appearance of negative T wave. (Hypertens Res 1993;16: 191-195)
Ohtani et al. (Fri,) studied this question.
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