Research in Arteriosclerosis—the First Fifty Years

Editorial1 September 1958RESEARCH IN ARTERIOSCLEROSIS—THE FIRST FIFTY YEARSWILLIAM DOCK, M.D.WILLIAM DOCK, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-3-699 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe year 1958 marks the fiftieth anniversary of the first successful experimental study of arteriosclerosis, the greatest killer of our century. The first experiment on tuberculosis had been completed forty years previously. Villemin's demonstration of tuberculosis in rabbits inoculated with human material made possible the isolation of the bacillus by Koch, and all subsequent studies of host sensitivity, diagnostic and therapeutic methods. It marked the beginning of the end of tuberculosis as an uncontrollable plague of city dwellers.When Ignatovski, of the Russian Imperial Military Medical Academy, reported in 1908 that rabbits fed milk and egg yolk developed severe arteriosclerosis,1...1 Ignatovski AI: On the influence of animal food on the tissues of the rabbit. Reports of the Imperial Military Medical Academy, Saint Petersburg 16: 154, 1908. Google Scholar2 Stuckey NW: On changes in the aorta of the rabbit due to feeding with different types of fat, Centralbl f. allg. Path u. path. Anat. 23: 910, 1912. Google Scholar3 AnichkovChalatov NS: On experimental cholesterol steatosis and its significance in the development of various pathologic processes, Centralbl. f. allg. Path u. path. Anat. 24: 1, 1913. Google Scholar4 Myasnikov AL: Influence of some factors on development of experimental cholesterol atherosclerosis, Circulation 17: 99, 1958. 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Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAtherosclerosis pathogenesis from the perspective of microvascular dysfunction Reflections on Atherosclerosis: Lesson from the Past and Future Research Directions Prof. Aleksandar Josifovich Ignjatovski, Founder and First Director of the Clinic for Internal Medicine and the First Head of the Department of Internal Medicine at the Faculty of Medicine in Skopje, R. 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