A DNA marker at the Harvey ras-1 locus was linked to long QT syndrome with a lod score of 16.44 at theta = 0, localizing the gene to the short arm of chromosome 11.
Observational
Effect estimate: lod score 16.44
Genetic factors contribute to heart disease. In this study, linkage analyses have been performed in a family that is predisposed to sudden death from cardiac arrhythmias, the long QT syndrome (LQT). A DNA marker at the Harvey ras-1 locus (H-ras-1) was linked to LQT with a logarithm of the likelihood ratio for linkage (lod score) of 16.44 at theta = 0, which confirms the genetic basis of this trait and localizes this gene to the short arm of chromosome 11. As no recombination was observed between LQT and H-ras-1, and there is a physiological rationale for its involvement in this disease, ras becomes a candidate for the disease locus.
Keating et al. (Fri,) conducted a observational in Long QT syndrome (LQT). Harvey ras-1 locus (H-ras-1) DNA marker was evaluated on Genetic linkage to LQT (lod score 16.44). A DNA marker at the Harvey ras-1 locus was linked to long QT syndrome with a lod score of 16.44 at theta = 0, localizing the gene to the short arm of chromosome 11.
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