Pamidronate can be safely incorporated with chemotherapy for the treatment of osteosarcoma. It does not impair the efficacy of chemotherapy. Pamidronate may improve the durability of limb reconstruction.

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Meyers et al. (Mon,) studied this question.

synapsesocial.com/papers/69dfedef6324afb55d593079 https://doi.org/https://doi.org/10.1002/cncr.25744

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1High-dose ifosfamide in advanced osteosarcoma.1985 · 89 citations
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3Bisphosphonates induce apoptosis in human myeloma cell lines: a novel anti‐tumour activity1997 · 404 citations
4Invited Commentary2009 · 2 citations
5Doxorubicin in Disseminated1972 · 152 citations

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1High-dose ifosfamide in advanced osteosarcoma.1985 · 89 citations
2Efficacy of the third-generation bisphosphonate risedronate alone and in combination with anticancer drugs against osteosarcoma cell lines.2008 · 27 citations
3Bisphosphonates induce apoptosis in human myeloma cell lines: a novel anti‐tumour activity1997 · 404 citations
4Invited Commentary2009 · 2 citations
5Doxorubicin in Disseminated1972 · 152 citations