July 10, 2012Journal of the American Chemical Society58 citations

Total Synthesis of (−)-Isoschizogamine

YMYusuke Miura NHNoriyuki Hayashi SYSatoshi Yokoshima

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Abstract

A first asymmetric total synthesis of (-)-isoschizogamine has been accomplished. Our synthesis features the facile construction of the carbon framework of the natural product through a Wagner-Meerwein rearrangement, a tandem metathesis, a stereoselective rhodium-mediated 1,4-addition of an arylboronic acid, and a ring-closing metathesis via a hemiaminal ether.

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Miura et al. (2012) studied this question.

synapsesocial.com/papers/6a881b6e04120b0d52eb4021 https://doi.org/https://doi.org/10.1021/ja305856q

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