Infants with a history of an apparent life-threatening event exhibited a significantly greater increase in R-R intervals during CO2 breathing compared to matched controls (45.1% vs. 41.4%; p=0.005).
Case-Control (n=82)
82 infants, comprising 41 who experienced an apparent life-threatening event and 41 matched controls, assessed for cardiac variability responses to a CO2 challenge during quiet sleep.
History of an apparent life-threatening event (ALTE) vs Gender- and age-matched control infants
Increase in R-R intervals during CO2 breathing, p=0.005
Absolute Event Rate: 45.1% vs 41.4%
p-value: p=0.005
AIM: To determine instantaneous cardiac variability responses to increased carbon dioxide (CO2) during quiet sleep in infants who may be at risk for the Sudden Infant Death syndrome (SIDS). METHODS: The cardiac rate variability before, during and after a CO2 challenge was examined in 41 infants who had experienced an apparent life-threatening event (ALTE) and 41 gender- and age-matched control infants. RESULTS: The ALTE infants responded to CO2 breathing with a significant increase in R-R intervals, i.e. decreases in heart rate, compared to the controls (45.1% increase in R-R intervals vs. 41.4%; p = 0.005). The differences between ALTE infants and controls depended primarily on the boys' responses. CONCLUSION: ALTE infants, particularly ALTE boys, have an autonomic dysfunction-lower sympathetic stimulation and/or inhibited vagal withdrawal when stressed with CO2. The outcome might provide clues to the mechanisms underlying the cardiovascular processes contributing to the terminal event in SIDS.
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Ann Edner
Uppsala University
Mats Ericson
KTH Royal Institute of Technology
J Milerad
Sachs' Children and Youth Hospital
Acta Paediatrica
Karolinska Institutet
KTH Royal Institute of Technology
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Edner et al. (Sun,) conducted a case-control in Apparent life-threatening event (ALTE) (n=82). History of an apparent life-threatening event (ALTE) vs. Gender- and age-matched control infants was evaluated on Increase in R-R intervals during CO2 breathing (p=0.005). Infants with a history of an apparent life-threatening event exhibited a significantly greater increase in R-R intervals during CO2 breathing compared to matched controls (45.1% vs. 41.4%; p=0.005).
synapsesocial.com/papers/6a231c0779e2b642a7fb2254 — DOI: https://doi.org/10.1111/j.1651-2227.2002.tb02827.x