July 19, 2000

Relationship of Baseline Serum Cholesterol Levels in 3 Large Cohorts of Younger Men to Long-term Coronary, Cardiovascular, and All-Cause Mortality and to Longevity

Structured PICO

Does baseline serum cholesterol level affect long-term risk of CHD, CVD, all-cause mortality, and longevity in younger men?

Population

Younger men from 3 large cohorts

Intervention

Elevated baseline serum cholesterol levels

Comparator

Favorable baseline serum cholesterol levels

Outcome

Long-term coronary heart disease (CHD), cardiovascular disease (CVD), and all-cause mortality, and estimated life expectancyhard clinical

Elevated baseline serum cholesterol in younger men is associated with a continuous, graded increase in long-term risk of CHD, CVD, and all-cause mortality.

Abstract

These results demonstrate a continuous, graded relationship of serum cholesterol level to long-term risk of CHD, CVD, and all-cause mortality, substantial absolute risk and absolute excess risk of CHD and CVD death for younger men with elevated serum cholesterol levels, and longer estimated life expectancy for younger men with favorable serum cholesterol levels. JAMA. 2000;284:311-318

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