LPL gene polymorphisms significantly impacted CHD risk, with the 9N allele increasing risk (OR 1.33; 95% CI 1.14-1.56) and the HindIII (OR 0.89) and 447X (OR 0.84) alleles decreasing risk.
Meta-Analysis (n=72,911)
Do specific LPL gene polymorphisms affect lipid fractions and the risk of coronary heart disease?
Specific LPL gene polymorphisms (9N, HindIII, 447X) are significantly associated with altered lipid profiles and coronary heart disease risk, confirming the close interrelations between HDL and triglyceride pathways.
Effect estimate: OR 1.33 (95% CI 1.14, 1.56)
Lipoprotein lipase (LPL) is a key enzyme in lipoprotein metabolism and a major candidate gene for coronary heart disease (CHD). The authors assessed associations between 7 LPL polymorphisms and lipid fractions and CHD risk in population-based cohort, case-control, and cross-sectional studies published by January 2007. Meta-analyses of 22,734 CHD cases and 50,177 controls in 89 association studies focused on the relations of the T-93G (rs1800590), D9N (rs1801177), G188E, N291S (rs268), PvuII (rs285), HindIII (rs320), and S447X (rs328) polymorphisms to high density lipoprotein cholesterol, triglycerides, myocardial infarction, or coronary stenosis. Carriers of 9N or 291S had modestly adverse lipid profiles. Carriers of the less common allele of HindIII or of 447X had modestly advantageous profiles. The combined odds ratio for CHD among carriers was 1.33 (95% confidence interval (CI): 1.14, 1.56) for 9N, 1.07 (95% CI: 0.96, 1.20) for 291S, 0.89 (95% CI: 0.81, 0.98) for the less common HindIII allele, and 0.84 (95% CI: 0.75, 0.94) for 447X. For T-93G (odds ratio (OR) = 1.22, 95% CI: 0.98, 1.52) and PvuII (OR = 0.96, 95% CI: 0.89, 1.04), there were null associations with lipid levels or CHD risk; information on G188E was limited (OR = 2.80, 95% CI: 0.88, 8.87). The study of LPL genotypes confirms the existence of close interrelations between high density lipoprotein cholesterol and triglyceride pathways. The influence of these genotypes on CHD risk warrants further investigation.
Sagoo et al. (Wed,) conducted a meta-analysis in Coronary heart disease (CHD) (n=72,911). LPL gene polymorphisms (T-93G, D9N, G188E, N291S, PvuII, HindIII, S447X) was evaluated on Coronary heart disease (OR 1.33, 95% CI 1.14, 1.56). LPL gene polymorphisms significantly impacted CHD risk, with the 9N allele increasing risk (OR 1.33; 95% CI 1.14-1.56) and the HindIII (OR 0.89) and 447X (OR 0.84) alleles decreasing risk.
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