Nonvalvular atrial fibrillation increased the relative risk of stroke compared to the general population, peaking at RR 12.6 in 41-50 year-olds and decreasing to RR 2.6 in 71-80 year-olds.
Observational (n=600)
What is the risk of cerebral infarction in patients with nonvalvular atrial fibrillation compared to the general population, and how is it affected by age, hypertension, and antihypertensive treatment?
In patients with nonvalvular atrial fibrillation, the relative risk of stroke compared to the general population is highest in younger patients, and while hypertension increases stroke risk, antihypertensive treatment did not appear to mitigate this risk in this cohort.
Effect estimate: RR 12.6
The stroke risk was studied on 600 subjects with nonvalvular atrial fibrillation (NVAF) compared with the general population. The age-matched relative risk of stroke was highest in the 41- to 50-year-old population (12.6) but decreased with age (8.2 for 51-60 years, 3.6 for 61-70 years, and 2.6 for 71-80 years) owing to the increase in stroke incidence with age in the general population. There was no particularly vulnerable period for stroke from NVAF diagnosis until the 15the year. Stroke incidence was greater in hypertensives than in normotensives, but was not different between treated and untreated subjects among hypertensives.
Tohgi et al. (Fri,) conducted a observational in Nonvalvular atrial fibrillation (n=600). Nonvalvular atrial fibrillation vs. General population was evaluated on Stroke (RR 12.6). Nonvalvular atrial fibrillation increased the relative risk of stroke compared to the general population, peaking at RR 12.6 in 41-50 year-olds and decreasing to RR 2.6 in 71-80 year-olds.