Cationic Planar Chiral Palladium P,S Complexes as Highly Efficient Catalysts in the Enantioselective Ring Opening of Oxa‐ and Azabicyclic Alkenes

Open plan: Cationic methylpalladium(II) complexes of planar chiral Fesulphos ligands (Fesulphos=1-phosphanyl-2-sulfenylferrocene) show excellent performance in the alkylative ring opening of oxa- and azabicyclic alkenes with dialkyl zinc reagents (see scheme, Cy=cyclohexyl, ArF=3,5-bis(trifluoromethyl)phenyl). Catalyst loadings as low as 0.5 mol % are normally sufficient to achieve high enantioselectivities (94–>99 % ee).