Low-dose aspirin (75 mg and 300 mg) significantly inhibited arachidonic acid-induced mean vasodilation by 55% and 59% in patients with congestive heart failure.
Does low-dose aspirin inhibit arachidonic acid-induced vasodilation in patients with congestive heart failure treated with ACE inhibitors?
Even low-dose aspirin (75 mg) significantly inhibits arachidonic acid-induced vasodilation in heart failure patients, suggesting potential detrimental vasoconstrictor effects.
Effect estimate: 55% and 59% inhibition
BACKGROUND: There is some evidence that aspirin may be harmful to patients with congestive heart failure treated with angiotensin-converting enzyme (ACE) inhibitors, but there has never been any direct examination of the vascular effects of aspirin in these patients. We sought to determine whether there is an arachidonic acid-dependent vasodilator pathway in resistance arteries in humans, whether it is affected by congestive heart failure, and whether it is inhibited by low-dose aspirin. METHODS: A locally active dose of arachidonic acid was infused into the nondominant brachial artery while forearm blood flow was measured by venous occlusion plethysmography in 10 healthy subjects in a control group and 15 patients with congestive heart failure treated with ACE inhibitor. Patients with congestive heart failure were studied after administration of 0 mg, 75 mg, and 300 mg aspirin for 14 days. RESULTS: Arachidonic acid produced progressive and incremental vasodilation (up to 64%). There was no significant difference between patients and healthy control subjects studied after administration of 0 mg aspirin. In patients, however, administration of 75 mg and 300 mg aspirin inhibited mean vasodilation by 55% and 59%, respectively. CONCLUSIONS: There is an arachidonic acid-dependent vasodilator pathway in humans. This pathway is not significantly affected by congestive heart failure. It is significantly inhibited by even low-dose aspirin therapy. These results imply that even the very lowest dose of aspirin in common use for cardioprotection has potentially detrimental vasoconstrictor effects.
Andrew Davie (Mon,) conducted a other in Congestive heart failure (n=25). Aspirin vs. 0 mg aspirin was evaluated on Arachidonic acid-induced vasodilation (55% and 59% inhibition). Low-dose aspirin (75 mg and 300 mg) significantly inhibited arachidonic acid-induced mean vasodilation by 55% and 59% in patients with congestive heart failure.