Essential hypertension significantly decreased left ventricular diastolic function compared to normotensive controls, with a peak lengthening rate of 3.08 s-1 versus 3.80 s-1.
Cross-Sectional (n=215)
No
In mild to moderate essential hypertension, LV diastolic function is impaired early and worsens with increased LV mass, while systolic impairment occurs specifically in eccentric hypertrophy due to inadequate adaptation to systolic load.
Absolute Event Rate: 3.08% vs 3.8%
p-value: p=<0.01
To elucidate left ventricular (LV) cardiac structure and function in patients with mild to moderate essential hypertension, we studied the relationship between LV geometry and function. We evaluated LV diastolic and systolic functions by M-mode echocardiography in 91 age-matched normotensive control subjects (NT) and 124 patients with essential hypertension. Hypertensive patients were divided into two groups based on the WHO stage classification: WHO I (n = 76) and WHO II (n = 48). Patients in WHO I and WHO II were further categorized according to the relative wall thickness as normal left ventricle (n = 47), concentric remodeling (n = 29), concentric hypertrophy (n = 25), and eccentric hypertrophy (n = 23). LV diastolic function was significantly decreased in the hypertensive groups compared to NT. There was no significant difference in LV systolic performance among NT, WHO I and WHO II. LV contractility was significantly increased in WHO I compared to NT. In respect to ventricular geometric pattern, LV diastolic function was significantly decreased in both the concentric hypertrophy and eccentric hypertrophy groups. LV systolic dysfunction was noted only in the eccentric hypertrophy group. In conclusion, patients with concentric remodeling had normal systolic and diastolic functions. LV diastolic function was impaired in both the concentric and eccentric hypertrophy groups due to an increase in LVMi. Moreover, LV systolic impairment was noted in the eccentric hypertrophy group due to an inappropriate compensation to LV systolic load.
Lin et al. (Sun,) conducted a cross-sectional in Mild to moderate essential hypertension (n=215). Essential hypertension vs. Normotensive control subjects was evaluated on Peak lengthening rate (LV diastolic function) (p=<0.01). Essential hypertension significantly decreased left ventricular diastolic function compared to normotensive controls, with a peak lengthening rate of 3.08 s-1 versus 3.80 s-1.