Postmenopausal women in the lowest quintile of self-perceived physical health had an 80% higher risk of incident cardiovascular disease compared to those in the highest quintile (HR 1.80).
Cohort (n=20,308)
Yes
Does self-perceived physical health predict cardiovascular disease incidence and death in postmenopausal women?
Self-reported physical health, as measured by the SF-36 Physical Component Summary, is a strong independent predictor of incident cardiovascular disease and mortality in postmenopausal women.
Hazard Ratio: 1.8 (95% CI 1.43–2.27)
p-value: p=<0.0001
BACKGROUND: Physical and Mental Component Summary (PCS, MCS, respectively) scales of SF- 36 health-related-quality-of-life have been associated with all-cause and cardiovascular disease (CVD) mortality. Their relationships with CVD incidence are unclear. This study purpose was to test whether PCS and/or MCS were associated with CVD incidence and death. METHODS: Postmenopausal women (aged 50-79 years) in control groups of the Women's Health Initiative clinical trials (n = 20,308) completed the SF-36 and standardized questionnaires at trial entry. Health outcomes, assessed semi-annually, were verified with medical records. Cox regressions assessed time to selected outcomes during the trial phase (1993-2005). RESULTS: A total of 1075 incident CVD events, 204 CVD-specific deaths, and 1043 total deaths occurred during the trial phase. Women with low versus high baseline PCS scores had less favorable health profiles at baseline. In multivariable models adjusting for baseline confounders, participants in the lowest PCS quintile (reference = highest quintile) exhibited 1.8 (95%CI: 1.4, 2.3), 4.7 (95%CI: 2.3, 9.4), and 2.1 (95%CI: 1.7, 2.7) times greater risk of CVD incidence, CVD-specific death, and total mortality, respectively, by trial end; whereas, MCS was not significantly associated with CVD incidence or death. CONCLUSION: Physical health, assessed by self-report of physical functioning, is a strong predictor of CVD incidence and death in postmenopausal women; similar self-assessment of mental health is not. PCS should be evaluated as a screening tool to identify older women at high risk for CVD development and death.
Saquib et al. (Tue,) conducted a cohort in Cardiovascular disease risk (n=20,308). Low self-perceived physical health (lowest PCS quintile) vs. High self-perceived physical health (highest PCS quintile) was evaluated on Cardiovascular disease incidence (HR 1.80, 95% CI 1.43-2.27, p=<0.0001). Postmenopausal women in the lowest quintile of self-perceived physical health had an 80% higher risk of incident cardiovascular disease compared to those in the highest quintile (HR 1.80).
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