Cyanosis on admission and underlying chronic illness were independently associated with a significantly increased risk of prolonged hospital stay (OR 7.4 and OR 2.5, respectively) in children with viral severe acute respiratory infections.
Observational (n=380)
Yes
In children hospitalized with viral severe acute respiratory infections, cyanosis and underlying chronic illness are significant risk factors for prolonged hospital stay.
Effect estimate: OR 7.4 (95% CI 1.8-30.32)
p-value: p=0.005
INTRODUCTION: Severe acute lower respiratory infections (SARIs) are one of the major causes of morbidity and mortality in young children, especially in developing countries. The present study focused on detection of risk factors for prolonged hospital stays among children with viral SARIs. METHODOLOGY: A sentinel surveillance study was conducted at Cairo University Hospital (CUH) between February 2010 and May 2011. Nasopharyngeal (NP) and oropharyngeal (OP) swabs were collected from all children admitted with SARIs. Viruses were identified using reverse transcription polymerase chain reaction (RT-PCR). RESULTS: Out of 1,046 children, 380 (36%) were positive for one or more viruses; these included respiratory syncytial virus (RSV) (22.9%), adenovirus (6.2%), parainfluenza viruses (PIVs1-3) (5.1%), human metapneumovirus (HMPV) (4.5%), influenza A (1.4%), and influenza B (0.6%). Viral etiology was mainly detected in children under one year of age (88.9%). Prolonged length of stay was independently associated with the presence of cyanosis and underlying chronic illness (OR 7.4, CI: 1.8-30.32 p = 0.005, OR 2.5, CI: 1.36-4.64 p = 0.004, respectively). Virus type did not affect the length of hospital stay (p > 0.05). Oxygen therapy was required in 91% of the patients. A total of 43 patients (11.6%) required intensive care admission. Twenty-one patients (5.5%) died, and 15 of them (71.4%) had an underlying chronic illness. CONCLUSIONS: The study demonstrated the important burden of respiratory viruses as a cause of SARI in hospitalized children in a tertiary Egyptian hospital. Cyanosis and underlying chronic illness were significantly associated with prolonged length of stay.
El‐Kholy et al. (Tue,) conducted a observational in Viral severe acute respiratory infections (SARIs) (n=380). Cyanosis on admission vs. Absence of cyanosis was evaluated on Prolonged length of stay (> 10 days) (OR 7.4, 95% CI 1.8-30.32, p=0.005). Cyanosis on admission and underlying chronic illness were independently associated with a significantly increased risk of prolonged hospital stay (OR 7.4 and OR 2.5, respectively) in children with viral severe acute respiratory infections.