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Transient alterations in brain oxygenation during 60-s periods of anoxia were visualized at high spatial resolution (voxel size or = 6 s) of halothane-anesthetized rats in vivo. Difference images from normoxia and anoxia exploit the signal decrease associated with increased levels of paramagnetic deoxyhemoglobin in the arterial and venous blood pool. Insights into the spatial heterogeneity of oxygen deprivation are complemented by physiologic information from the time course of pertinent signal changes in different regions of the brain.
Prielmeier et al. (Wed,) studied this question.