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Mixed leukocyte culture tests were carried out on a heterogeneous but genetically defined backcross population of rats to determine whether the reactions observed were related to histoincompatibility. The genetic situation precluded two-way reactions. Only when the two donors of a leukocyte mixture differed at the important Ag-B histocompatibility locus was there any in vitro reactivity, and a difference at this locus was always associated with an acute homograft reaction. Compatibility at this locus proved to be important in that it facilitated the prolongation of survival of skin homografts by immunosuppressive therapy.
Silvers et al. (Sat,) studied this question.